This week, Year 12 Human Biology students have been running Polymerase Chain Reactions to amplify DNA and Gel Electrophoresis techniques to separate the DNA. Students completed these techniques to identify mutated sequences in the Cystic Fibrosis Conductance Regulator Gene, which is located on Chromosome number 7. The gene codes for a specific protein responsible for chloride ion transport. When this gene is defective due to mutations in the code, it results in a build-up of sticky mucous in multiple organs and results in the Cystic Fibrosis disorder.

Learning how Science uses these techniques to detect disease sequences is a key component of the Human Biology course. These procedures also have wider uses such as in disease management, forensics, paternity tests and mapping out evolutionary pathways of different species.

Mr Shane Willshire
Science Teacher